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Volume 29 , Issue 5
September/October 2009
Pages 549-555

Time Sequence of Bone Healing Around Two Implant Systems in Minipigs: Preliminary Histologic Results

Daniela Carmagnola, DDS, PhD/Silvio Abati, MD, DDS/Alessandro Addis, DVM/Giovanni Ferrieri, MD, DMD/Matteo Chiapasco, MD/Eugenio Romeo, MD, DMD/Giorgio Vogel

PMID: 19888499
DOI: 10.11607/prd.00.0878

The aim of this study was to evaluate the early phases of bone healing around two different implant surfaces. For this purpose, four minipigs were used. Implants with rough titanium surfaces (ITI sandblasted/acid-etched and Brånemark TiUnite) were placed in the maxillae of the animals and sacrifice was scheduled in such a way that healing times of 3 days, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, and 7 weeks were obtained. Histologic analysis revealed that a similar pattern was observed in the phases of bone healing around both types of implants between 3 days and 7 weeks. This pattern consisted of the replacement of blood clot and bone debris with a provisional connective tissue in the first few weeks and with mineralized tissue and marrow spaces later on. Both rough surfaces allowed for “contact osteo­genesis” to take place. (Int J Periodontics Restorative Dent 2009;29:549–555.)

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